Dermatofibrosarcoma protuberans (DFSP) is a rare, distinctive cutaneous tumor, which consists of spindle-shaped cells arranged in densely packed interlacing bundles with the storiform or cartwheel pattern. Histologically, it resembles deep
growing
dermatofibroma, nodular fasciitis, neurofibroma and neural sheath tumors. DFSP is one of the connective tissue tumors which is difficult to diagnose histologically as well as clinically.
Recently, the immunochemical staining with a monoclonal antibody to CD34 is reported to give assistance in the clear differential diagnosis of DFSP from other fibrous or neural tumors. Herein, three cases of DFSP were stained by
immunohistochemical
staining with S-100 protein, vimentin, factor VIII and anti-CD34 antibody in order to assess the use of anti-CD34 in the differential diagnosis of DFSP. (Kor J Dermatol 1997;35(2) : 327∼332)
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